Candidiasis (thrush) is a frequent companion of women at any time of pregnancy. The causative agent is the fungus of the genus Candida, which is a normal component of a healthy microflora of the skin and mucous membranes. With a decrease in immunity, chronic diseases, malnutrition, and an imbalance of hormones, the fungal microorganism begins to multiply uncontrollably and causes symptoms of the disease. Thrush is manifested by itching in the genital area and curdled discharge. In pregnancy, this disease carries a potential danger. It poses a threat not only to women, but also increases the risk of infection of the child during childbirth. Candidiasis requires compulsory treatment, in this case, only a doctor should select a drug.
Can Fluxostat be Pregnant?Flukostat is considered to be an active antifungal drug having a systemic effect. Its components penetrate all tissues, organs and are found in them for a long time. In addition to Candida, this drug is capable of destroying the cryptococcal and coccidioid microflora. The action of the active component of fluconazole is aimed at inhibiting fungal enzymes, so that they stop multiplying. At the same time existing colonies die independently and do not spread.
Flucostat analogues are preparations Fucis, Diflucan, Fluconazole, Mycosyst. All of them are prohibited for use during pregnancy and lactation. In addition to the fact that their active components penetrate all tissues and liquids, they easily overcome the barrier in the form of the placenta. Fluconazole adversely affects not only the fungal microflora, but also is a toxin that disrupts internal processes in the body and adversely affects the development of the fetus.For the treatment of candidiasis during pregnancy, doctors choose more gentle means that do not have a pronounced toxic effect. Fluxostat is used exclusively in rare cases in the generalized form of candidiasis.
Indications for use Flucostat in pregnancyAt pregnancy Flucostat is forbidden to application. But there are some exceptional cases in which the use of powerful drugs is permitted. Sometimes in the body of a pregnant woman conditions are created for extensive fungal spread, which covers the entire body. 75% of such generalized lesions of internal and external tissues result in death. Even an ordinary thrush on the mucous membrane of the mouth or vagina can suddenly become a systemic fungal infection of the whole organism. This process is promoted by diseases that reduce immune defense, for example, leukemia, HIV infection and diabetes mellitus. When generalized fungal lesions of the whole body often have to fight for the life of a woman. At the same time, the condition of the fetus and the course of pregnancy go into the background. In such rare cases, the use of Flucostat is justified.
Contraindications to the use of Flucostat in pregnancyBy itself, pregnancy is a contraindication to taking Flucostat. The US Drug Control Administration developed a list of drugs that are dangerous for pregnant women. Six categories of various pharmaceutical products were identified. According to the list, Flukostat belongs to the category C. This includes drugs, which during the studies showed their negative impact on fetal development in animals. Due to ethical considerations, such experiments can not be conducted on pregnant women, but the similarity of physiological processes between humans and animals indicates a high probability of negative impact on the future child when using drugs based on fluconazole. For this reason, doctors do not prescribe a drug to treat pregnant women, but prefer other antimycotic drugs that do not affect the fetus destructively.
Side effects of FlucostatAs stated above, no experiments have been performed with pregnant women to confirm the negative effect of Flucostat. However, at the present time, there are data on children whose mothers took the medication for treatment of thrush uncontrollably for three months. These children showed birth defects, which are presumably due to the teratogenic and embryotoxic effect of the drug. Based on these facts it is believed that taking more than 400 mg / day of fluconazole, is capable of adversely affecting the development of the fetus. The standard side effects that occur in response to Flucostat in pregnant women are the following:
- attacks of nausea, taste change, indigestion;
- yellowing of the eye sclera and skin;
- dizziness, headaches, convulsions;
- heart rhythm disorder;
- allergic reactions.
Flucostat in planning and early pregnancyFlucostat has specific properties, thanks to which the process of removing fluconazole from the body is quite long, for several weeks. Even after six months, the analysis of nail plates reveals the remains of this substance. Treatment Flucostat should be performed before the beginning of the period of pregnancy planning or replace it with a more sparing drug. If you still had to use it, then the moment of conception is better to postpone.
Taking drugs based on fluconazole in the first weeks of pregnancy can lead to the development of heart defects in a future child. At the beginning of the first trimester, vital organs and the cardiovascular system are laid. A woman may not be aware of her pregnancy during this period and perform antifungal therapy.Statistics indicate that in women who took Flukostat in pregnancy, the frequency of the birth of children with heart defects was 3 times more common. Higher doses of the drug are capable of provoking a number of birth defects in children, such as defects in the maxillofacial area and the pathology of the musculoskeletal system. These observations proved the inadmissibility of using Flucostat during pregnancy.